Régulation Fonctionnelle et Surveillance de l'ARN



Delan-Forino C., Maurel M-C., Torchet C. (2011). Replication of avocado sunblotch viroid in the yeast Saccharomyces cerevisiae. J Virol. 85:3229-38.


Mathy, N.,  Hébert, A., Mervelet, P., Bénard, L., Dorléans, P., Li de la Sierra-Gallay, I., Noirot, P., Putzer, H., and C. Condon. (2010) B. subtilis ribonucleases J1 and J2 form a complex  with altered enzyme behaviour. Mol Microbiology, 75:489-498.


Li Y.L., Vergne J., Torchet C., Maurel M.C. (2009). In vitro selection of adenine-dependent ribozyme against Tpl2/Cot oncogene. FEBS J. 276(1):303-14

Sinturel F, Pellegrini O, Xiang S, Tong L, Condon C and Bénard L. (2009) Real-time fluorescence detection of exoribonucleases. RNA. 2009 Sep 18, 2057-2062.

Daou-Chabo, R., Mathy, N., Bénard, L. & Condon, C. (2009). Ribosomes initiating translation of the hbs mRNA protect it from 5’-to-3’ exoribonucleolytic degradation by RNase J1. Mol Microbiology 71, 1538-1550.


Condon C., Pellegrini O., Mathy N., Bénard L., Redko Y., Oussenko IA., Deikus G.,  and Bechhofer, D.H. (2008) Assay of Bacillus subtilis ribonucleases in vitro. Methods in Enzymology 447, 277-308

Pellegrini O, Mathy N, Condon C, and Bénard, L. (2008) In vitro assays of 5’ to 3'-exoribonuclease activity. Methods in Enzymology 448, 167-183


Mathy*, N., Bénard*, L., Pellegrini, O., Daou, R., Wen, T. & Condon, C. (2007). 5’-to-3’ exoribonuclease activity in bacteria : role of RNase J1 in rRNA maturation and 5’ stability of mRNA. Cell 129, 681-692. * Co-first authors.

Torchet C., Maurel M.C. (2007). RNAs in extreme environments. Chem Biodivers. 4:1957-1971.

Li Y.L., Torchet C., Vergne J., Maurel M.C. (2007). A cis and trans adenine-dependent hairpin ribozyme against Tpl-2 target. Biochimie. 89:1257-1263.


Todeschini, A. L., Condon, C., and Benard, L. (2006). Sodium-induced GCN4 expression controls the accumulation of the 5' to 3' RNA degradation inhibitor, 3'-phosphoadenosine 5'-phosphate. J Biol Chem 281, 3276-3282.


Milligan L., Torchet C., Allmang C., Shipman T., Tollervey D. (2005). A nuclear surveillance pathway for mRNAs with defective polyadenylation, Mol Cell Biol. 25:9996-10004.

Torchet C., Badis G., Devaux F., Costanzo G., Werner M., Jacquier A. (2005). The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae. Rna. 11:928-938.


Bénard, L. “ Inhibition of 5' to 3' mRNA degradation under stress conditions in Saccharomyces cerevisiae: from GCN4 to MET16 ”. RNA (2004), 10:458-468.


Ganem C., Devaux F., Torchet C., Jacq C., Quevillon-Cheruel S., Labesse G., Facca C., Faye G. (2003). Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast. Embo J. 22:1588-1598.


Morillon, A ., Bénard, L., Springer, M., and P. Lesage. “ Differential effects of chromatin and Gcn4 on the 50-fold range of expression among individual yeast Ty1 retrotransposons ”.Mol. Cell. Biol., (2002), Apr;22(7):2078-88.

Torchet C., Bousquet-Antonelli C., Milligan L., Thompson E., Kufel J., Tollervey D. (2002). Processing of 3'-extended read-through transcripts by the exosome can generate functional mRNAs. Mol Cell. 9:1285-1296.

Torchet C., Hermann-Le Denmat S. (2002). High dosage of the small nucleolar RNA snR10 specifically suppresses defects of a yeast rrp5 mutant. Mol Genet Genomics. 268:70-80.


Serganov, A., Bénard, L., Portier, C., Ennifar, E., Garber, M., Ehresmann, B. et C. Ehresmann.“ Role of conserved nucleotides in building the 16 S rRNA binding site for ribosomal protein S15 ”.J. Mol. Biol., (2001), Jan. 26;305(4):785-803.


Torchet C., Hermann-Le Denmat S. (2000). Bypassing the rRNA processing endonucleolytic cleavage at site A2 in Saccharomyces cerevisiae. Rna. 6 :1498-1508.


Bénard, L., Carroll, K., Valle, RC., Masison, DC., and R.B. Wickner. (1999) “ The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae ”. J. Virol. , Apr;73(4):2893-900.

Bénard, L., Edskes, H., Ribas, J. C. & Wickner, R. B. (1999) Yeast RNA viruses. In : Encyclopedia of virology, 2nd Edition.


Bénard, L., Carroll K., Valle, R., and R.B. Wickner. (1998) “ Ski6p, a new homolog of RNA processing enzymes affects translation of non-poly(A) mRNAs and 60S ribosomal subunit biogenesis ” 19 Mol. Cell. Biol. , Vol 18, pp. 2688-2696.

Bénard, L., Mathy, N., Grunberg-Manago, M., Ehresmann, B., Ehresmann, C. and C. Portier. (1998) “ Identification in a pseudoknot of a U.G motif essential for the regulation of the expression of ribosomal protein S15 ” Proc. Natl. Acad. Sci USA, , 95(5), pp. 2564-2567.

Torchet C., Jacq C., Hermann-Le Denmat S. (1998). Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiae. Rna. 4 :1636-1652.


Bénard, L., Philippe, C., Ehresmann, B., Ehresmann, C. and C. Portier. “ Pseudoknot and translation control in the expression of the S15 ribosomal protein ” Biochimie (1996) 78, pp. 568-576.


Philippe, C., Bénard, L., Portier, C., Westhof, E., Ehresmann, B. and C. Ehresmann. “ Mutational analysis of the pseudoknot structure of the S15 translational operator from E. coli ”.Nucleic Acids Research (1995), Vol 23(1), pp. 18-28.

Ehresmann, C., Philippe, C., Westhof, E., Bénard, L., Portier, C.,  and B. Ehresmann. “ A pseudoknot structure is required for efficient initiation and regulation of the E. coli rpsO mRNA coding for ribosomal protein S15. Biochem. Cell. Biol. (1995) 73:1131-1140.


Bénard, L., Philippe, C., Dondon, L., Grunberg-Manago, M., Ehresmann, B., Ehresmann, C. and C. Portier. “ Mutational analysis of the pseudoknot structure of the S15 translational operator from E. coli ”.Molecular Microbiology (1994), Vol 14(1), pp 31-40.

Philippe, C., Bénard, L., Eyermann, F., Cachia, C., Portier, C., Ehresmann, B. ,and C. Ehresmann. “ Structural element of rpsO mRNA involved in the modulation of translational initiation and regulation of E. coli ribosomal protein S15 ”.Nucleic Acids Research (1994), Vol 22(13), pp 2538-2546.


Philippe, C., Eyermann, F., Bénard, L., Portier, C., Ehresmann, B. and C. Ehresmann. “ Ribosomal protein S15 from E. coli modulates its own translation by trapping the ribosome on the mRNA initiation loading site ”.Proc. Natl. Acad. Sci USA (1993), Vol 90, pp 4394-4398.

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